ea0032p156 | Calcium and Vitamin D metabolism | ECE2013
Moniz Caje
, Couchman Lewis
, Krastins Bryan
, Lopez Mary
, Prakash Amol
, Sarracino David
, Vogelsang Mary
, Peterman Scott
, Vadali Gouri
, Robinson Sarah
Parathyroid hormone is involved in calcium homeostasis through interactions with vitamin D. Because intact and truncated forms of PTH vary in their biological activity, assays that can accurately quantify the ratio of intact hormone to its fragments are of increasing significance in the diagnosis of endocrine, renal and bone diseases. Vitamin D and its metabolites circulate tightly bound to vitamin D-binding protein (DBP). Because DBP concentrations are altered in pregnancy, l...